BN 80933, a dual inhibitor of neuronal nitric oxide synthase and lipid peroxidation: a promising neuroprotective strategy.

Chabrier, P E; Auguet, M; Spinnewyn, B; Auvin, S; Cornet, S; Demerlé-Pallardy, C; Guilmard-Favre, C; Marin, J G; Pignol, B; Gillard-Roubert, V; Roussillot-Charnet, C; Schulz, J; Viossat, I; Bigg, D; Moncada, S

Chabrier, P E; Auguet, M; Spinnewyn, B; Auvin, S; Cornet, S; Demerlé-Pallardy, C; Guilmard-Favre, C; Marin, J G; Pignol, B; Gillard-Roubert, V; Roussillot-Charnet, C; Schulz, J; Viossat, I; Bigg, D; Moncada, S.

Affiliation

Chabrier PE; Beaufour-Ipsen Research Laboratories, Institut Henri Beaufour, 5 Avenue du Canada, 91966 Les Ulis Cedex, France. pierreet.chabrier@beaufour-ipsen.com

Proc Natl Acad Sci U S A ; 96(19): 10824-9, 1999 Sep 14.

Article in En | MEDLINE | ID: mdl-10485910

Subject(s)

Enzyme Inhibitors/pharmacology; Lipid Peroxidation/drug effects; Nitric Oxide Synthase/antagonists & inhibitors; Pyrazines/pharmacology; Thiophenes/pharmacology; Animals; Aorta/metabolism; Brain Injuries/drug therapy; Dose-Response Relationship, Drug; Gerbillinae; Inhibitory Concentration 50; Kinetics; Male; Mice; Myocardial Ischemia/drug therapy; Neurons/enzymology; Neuroprotective Agents/pharmacology; Organ Culture Techniques; Pyrazines/chemistry; Rats; Rats, Sprague-Dawley; Thiophenes/chemistry; Time Factors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazines / Thiophenes / Lipid Peroxidation / Nitric Oxide Synthase / Enzyme Inhibitors Limits: Animals Language: En Journal: Proc Natl Acad Sci U S A Year: 1999 Type: Article Affiliation country: France

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