Inhibition of angiogenesis by thrombospondin-1 is mediated by 2 independent regions within the type 1 repeats.

Iruela-Arispe, M L; Lombardo, M; Krutzsch, H C; Lawler, J; Roberts, D D

Iruela-Arispe, M L; Lombardo, M; Krutzsch, H C; Lawler, J; Roberts, D D.

Affiliation

Iruela-Arispe ML; Department of Molecular, Cell, and Developmental Biology and the Molecular Biology Institute, UCLA, Los Angeles, Calif 90095, USA. arispe@mbi.ucla.edu

Circulation ; 100(13): 1423-31, 1999 Sep 28.

Article in En | MEDLINE | ID: mdl-10500044

Subject(s)

Neovascularization, Pathologic/prevention & control; Thrombospondin 1/genetics; Thrombospondin 1/pharmacology; Amino Acid Sequence/genetics; Animals; Cell Division/drug effects; Chick Embryo; Endothelial Growth Factors/antagonists & inhibitors; Endothelial Growth Factors/physiology; Endothelium, Vascular/cytology; Endothelium, Vascular/drug effects; Extraembryonic Membranes/blood supply; Extraembryonic Membranes/drug effects; Female; Fibroblast Growth Factor 2/antagonists & inhibitors; Fibroblast Growth Factor 2/physiology; Lymphokines/antagonists & inhibitors; Lymphokines/physiology; Mammary Neoplasms, Animal/pathology; Mice; Mice, Nude; Molecular Sequence Data; Peptide Fragments/genetics; Peptide Fragments/pharmacology; Recombinant Proteins; Repetitive Sequences, Amino Acid; Signal Transduction/drug effects; Transplantation, Heterologous; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Thrombospondin 1 / Neovascularization, Pathologic Type of study: Prognostic_studies Limits: Animals Language: En Journal: Circulation Year: 1999 Type: Article Affiliation country: United States

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