Axially chiral 1,7-naphthyridine-6-carboxamide derivatives as orally active tachykinin NK(1) receptor antagonists: synthesis, antagonistic activity, and effects on bladder functions.

Natsugari, H; Ikeura, Y; Kamo, I; Ishimaru, T; Ishichi, Y; Fujishima, A; Tanaka, T; Kasahara, F; Kawada, M; Doi, T

Natsugari, H; Ikeura, Y; Kamo, I; Ishimaru, T; Ishichi, Y; Fujishima, A; Tanaka, T; Kasahara, F; Kawada, M; Doi, T.

Affiliation

Natsugari H; Pharmaceutical Research Division and Technology Development Department, Takeda Chemical Industries, Ltd., 2-17-85, Jusohonmachi, Yodogawa-ku, Osaka 532-8686, Japan. Natsugari_Hideaki@takeda.co.jp

J Med Chem ; 42(19): 3982-93, 1999 Sep 23.

Article in En | MEDLINE | ID: mdl-10508446

Subject(s)

Naphthyridines/chemistry; Naphthyridines/pharmacology; Neurokinin-1 Receptor Antagonists; Urinary Bladder/physiology; Animals; Cell Line; Chromatography, High Pressure Liquid; Crystallography, X-Ray; Guinea Pigs; Humans; Magnetic Resonance Spectroscopy; Models, Chemical; Models, Molecular; Muscle Contraction/drug effects; Protein Conformation; Urinary Bladder/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Urinary Bladder / Neurokinin-1 Receptor Antagonists / Naphthyridines Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1999 Type: Article Affiliation country: Japan

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