Mutations in CYP11B1 gene converting 11beta-hydroxylase into an aldosterone-producing enzyme are not present in aldosterone-producing adenomas.

Pilon, C; Mulatero, P; Barzon, L; Veglio, F; Garrone, C; Boscaro, M; Sonino, N; Fallo, F

Pilon, C; Mulatero, P; Barzon, L; Veglio, F; Garrone, C; Boscaro, M; Sonino, N; Fallo, F.

Affiliation

Pilon C; Department of Medical and Surgical Sciences, University of Torino, Italy.

J Clin Endocrinol Metab ; 84(11): 4228-31, 1999 Nov.

Article in En | MEDLINE | ID: mdl-10566677

Subject(s)

Adenoma/metabolism; Adrenal Cortex Neoplasms/metabolism; Aldosterone/biosynthesis; Cytochrome P-450 CYP11B2/genetics; Mutation; Steroid 11-beta-Hydroxylase/genetics; Adenoma/genetics; Adrenal Cortex Neoplasms/genetics; Adult; Base Sequence; Blotting, Southern; Female; Humans; Hyperaldosteronism/genetics; Male; Middle Aged; Polymerase Chain Reaction; Sequence Analysis, DNA

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Collection: 01-internacional Database: MEDLINE Main subject: Steroid 11-beta-Hydroxylase / Adenoma / Adrenal Cortex Neoplasms / Cytochrome P-450 CYP11B2 / Aldosterone / Mutation Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: J Clin Endocrinol Metab Year: 1999 Type: Article Affiliation country: Italy

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