Enhanced morphine analgesia in mice lacking beta-arrestin 2.

Bohn, L M; Lefkowitz, R J; Gainetdinov, R R; Peppel, K; Caron, M G; Lin, F T

Bohn, L M; Lefkowitz, R J; Gainetdinov, R R; Peppel, K; Caron, M G; Lin, F T.

Affiliation

Bohn LM; Howard Hughes Medical Institute Laboratories, Departments of Cell Biology and Medicine, Duke University Medical Center, Durham, NC 27710, USA.

Science ; 286(5449): 2495-8, 1999 Dec 24.

Article in En | MEDLINE | ID: mdl-10617462

Subject(s)

Analgesics, Opioid/pharmacology; Arrestins/physiology; Morphine/pharmacology; Receptors, Opioid, mu/metabolism; Analgesia; Analgesics, Opioid/administration & dosage; Analgesics, Opioid/metabolism; Animals; Arrestins/genetics; Binding Sites; Body Temperature/drug effects; Brain/metabolism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-/pharmacology; GTP-Binding Proteins/metabolism; Guanosine 5'-O-(3-Thiotriphosphate)/metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine/administration & dosage; Morphine/metabolism; Naloxone/metabolism; Naloxone/pharmacology; Narcotic Antagonists/metabolism; Narcotic Antagonists/pharmacology; Pain Measurement; Pain Threshold; Phosphorylation; Signal Transduction; beta-Arrestin 1; beta-Arrestin 2; beta-Arrestins

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Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Opioid, mu / Arrestins / Analgesics, Opioid / Morphine Limits: Animals Language: En Journal: Science Year: 1999 Type: Article Affiliation country: United States

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