Pharmacokinetics of irinotecan and its metabolites SN-38 and APC in children with recurrent solid tumors after protracted low-dose irinotecan.

Ma, M K; Zamboni, W C; Radomski, K M; Furman, W L; Santana, V M; Houghton, P J; Hanna, S K; Smith, A K; Stewart, C F

Ma, M K; Zamboni, W C; Radomski, K M; Furman, W L; Santana, V M; Houghton, P J; Hanna, S K; Smith, A K; Stewart, C F.

Affiliation

Ma MK; Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, Tennessee 38105-2794, USA.

Clin Cancer Res ; 6(3): 813-9, 2000 Mar.

Article in En | MEDLINE | ID: mdl-10741701

Subject(s)

Antineoplastic Agents, Phytogenic/pharmacokinetics; Camptothecin/analogs & derivatives; Neoplasms/drug therapy; Adolescent; Adult; Antineoplastic Agents, Phytogenic/adverse effects; Antineoplastic Agents, Phytogenic/therapeutic use; Area Under Curve; Camptothecin/blood; Camptothecin/pharmacokinetics; Camptothecin/therapeutic use; Child; Child, Preschool; Diarrhea/chemically induced; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Irinotecan; Neoplasm Recurrence, Local; Neoplasms/pathology; Neoplasms, Complex and Mixed/drug therapy; Neoplasms, Complex and Mixed/pathology; Neoplasms, Connective and Soft Tissue/drug therapy; Neoplasms, Connective and Soft Tissue/pathology; Neoplasms, Glandular and Epithelial/drug therapy; Neoplasms, Glandular and Epithelial/pathology; Neutropenia/chemically induced; Time Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Camptothecin / Neoplasms / Antineoplastic Agents, Phytogenic Type of study: Clinical_trials / Prognostic_studies Limits: Adolescent / Adult / Child / Child, preschool / Humans Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2000 Type: Article Affiliation country: United States

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