Characterization of human recombinant alpha(2A)-adrenoceptors expressed in Chinese hamster lung cells using intracellular Ca(2+) changes: evidence for cross-talk between recombinant alpha(2A)- and native alpha(1)-adrenoceptors.

Reynen, P H; Martin, G R; Eglen, R M; MacLennan, S J

Reynen, P H; Martin, G R; Eglen, R M; MacLennan, S J.

Affiliation

Reynen PH; Department of Molecular Pharmacology, Center for Biological Research, Neurobiology Unit, Roche Bioscience, 3401 Hillview Avenue, Palo Alto, California, CA 94304, USA.

Br J Pharmacol ; 129(7): 1339-46, 2000 Apr.

Article in En | MEDLINE | ID: mdl-10742289

Subject(s)

Calcium/metabolism; Receptors, Adrenergic, alpha-2/metabolism; Adrenergic alpha-Agonists/pharmacology; Adrenergic alpha-Antagonists/pharmacology; Aniline Compounds; Animals; Azepines/pharmacology; Binding, Competitive; Brimonidine Tartrate; Cell Line; Cricetinae; Dexmedetomidine/pharmacology; Dose-Response Relationship, Drug; Doxazosin/pharmacology; Estrenes/pharmacology; Fluorescence; Gene Expression; Humans; Imidazoles/pharmacology; Norepinephrine/pharmacology; Prazosin/metabolism; Prazosin/pharmacology; Pyrrolidinones/pharmacology; Quinoxalines/pharmacology; Radioligand Assay; Receptor Cross-Talk; Receptors, Adrenergic, alpha-1/metabolism; Receptors, Adrenergic, alpha-2/drug effects; Receptors, Adrenergic, alpha-2/genetics; Recombinant Fusion Proteins/drug effects; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/metabolism; Signal Transduction/drug effects; Tetrahydronaphthalenes/pharmacology; Thapsigargin/pharmacology; Xanthenes; Yohimbine/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Calcium / Receptors, Adrenergic, alpha-2 Language: En Journal: Br J Pharmacol Year: 2000 Type: Article Affiliation country: United States

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