EWS-FLI1, EWS-ERG, and EWS-ETV1 oncoproteins of Ewing tumor family all suppress transcription of transforming growth factor beta type II receptor gene.

Im, Y H; Kim, H T; Lee, C; Poulin, D; Welford, S; Sorensen, P H; Denny, C T; Kim, S J

Im, Y H; Kim, H T; Lee, C; Poulin, D; Welford, S; Sorensen, P H; Denny, C T; Kim, S J.

Affiliation

Im YH; Laboratory of Cell Regulation and Carcinogenesis, DBS, National Cancer Institute, Bethesda, Maryland 20892-5055, USA.

Cancer Res ; 60(6): 1536-40, 2000 Mar 15.

Article in En | MEDLINE | ID: mdl-10749119

Subject(s)

Bone Neoplasms/genetics; DNA-Binding Proteins; Oncogene Proteins, Fusion/genetics; Receptors, Transforming Growth Factor beta/genetics; Sarcoma, Ewing/genetics; Trans-Activators; 3T3 Cells; Animals; Gene Expression Regulation; Humans; Luciferases/genetics; Luciferases/metabolism; Mice; Oncogene Proteins/genetics; Promoter Regions, Genetic/genetics; Protein Serine-Threonine Kinases; Proto-Oncogene Protein c-fli-1; RNA, Messenger/genetics; RNA, Messenger/metabolism; RNA-Binding Protein EWS; Radioligand Assay; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta/metabolism; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/metabolism; Transcription Factors/genetics; Transcription, Genetic; Transcriptional Regulator ERG; Transforming Growth Factor beta/metabolism; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Sarcoma, Ewing / Bone Neoplasms / Oncogene Proteins, Fusion / Trans-Activators / Receptors, Transforming Growth Factor beta / DNA-Binding Proteins Limits: Animals / Humans Language: En Journal: Cancer Res Year: 2000 Type: Article Affiliation country: United States

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