Pharmacokinetics, tissue distribution, metabolism, and excretion of celecoxib in rats.

Paulson, S K; Zhang, J Y; Breau, A P; Hribar, J D; Liu, N W; Jessen, S M; Lawal, Y M; Cogburn, J N; Gresk, C J; Markos, C S; Maziasz, T J; Schoenhard, G L; Burton, E G

Paulson, S K; Zhang, J Y; Breau, A P; Hribar, J D; Liu, N W; Jessen, S M; Lawal, Y M; Cogburn, J N; Gresk, C J; Markos, C S; Maziasz, T J; Schoenhard, G L; Burton, E G.

Affiliation

Paulson SK; Department of Clinical Pharmacokinetics and Bioavailability, G.D. Searle & Co., Skokie, Illinois, USA. Susan.K.Paulson@monsanto.com

Drug Metab Dispos ; 28(5): 514-21, 2000 May.

Article in En | MEDLINE | ID: mdl-10772629

Subject(s)

Anti-Inflammatory Agents, Non-Steroidal/pharmacokinetics; Sulfonamides/pharmacokinetics; Animals; Area Under Curve; Bile/metabolism; Bile Ducts/physiology; Biotransformation; Celecoxib; Chromatography, High Pressure Liquid; Feces/chemistry; Female; Half-Life; Injections, Intravenous; Male; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides/administration & dosage; Tissue Distribution

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Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Anti-Inflammatory Agents, Non-Steroidal Type of study: Prognostic_studies Limits: Animals Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2000 Type: Article Affiliation country: United States

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