The orally administered P-glycoprotein inhibitor R101933 does not alter the plasma pharmacokinetics of docetaxel.

van Zuylen, L; Sparreboom, A; van der Gaast, A; van der Burg, M E; van Beurden, V; Bol, C J; Woestenborghs, R; Palmer, P A; Verweij, J

van Zuylen, L; Sparreboom, A; van der Gaast, A; van der Burg, M E; van Beurden, V; Bol, C J; Woestenborghs, R; Palmer, P A; Verweij, J.

Affiliation

van Zuylen L; Department of Medical Oncology, Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital, Rotterdam, The Netherlands. l.van.zuylen@hetnet.nl

Clin Cancer Res ; 6(4): 1365-71, 2000 Apr.

Article in En | MEDLINE | ID: mdl-10778964

Subject(s)

ATP Binding Cassette Transporter, Subfamily B, Member 1/antagonists & inhibitors; Antineoplastic Agents, Phytogenic/pharmacokinetics; Benzazepines/pharmacology; Neoplasms/drug therapy; Paclitaxel/analogs & derivatives; Quinolines/pharmacology; Taxoids; Administration, Oral; Adult; Aged; Antineoplastic Agents, Phytogenic/adverse effects; Area Under Curve; Docetaxel; Dose-Response Relationship, Drug; Fatigue/chemically induced; Female; Humans; Male; Middle Aged; Mouth Mucosa/drug effects; Mouth Mucosa/pathology; Neoplasms/metabolism; Neoplasms/pathology; Neutropenia/chemically induced; Paclitaxel/adverse effects; Paclitaxel/blood; Paclitaxel/pharmacokinetics; Stomatitis/chemically induced; Vomiting/chemically induced

Search on Google

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Quinolines / Benzazepines / Paclitaxel / ATP Binding Cassette Transporter, Subfamily B, Member 1 / Taxoids / Neoplasms / Antineoplastic Agents, Phytogenic Type of study: Prognostic_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2000 Type: Article Affiliation country: Netherlands

Search on Google

XML

PubMed Links