Partners and pathwaysrepairing a double-strand break.
Trends Genet
; 16(6): 259-64, 2000 Jun.
Article
in En
| MEDLINE
| ID: mdl-10827453
ABSTRACT
Double-strand chromosome breaks can arise in a number of ways, by ionizing radiation, by spontaneous chromosome breaks during DNA replication, or by the programmed action of endonucleases, such as in meiosis. Broken chromosomes can be repaired either by one of several homologous recombination mechanisms, or by a number of nonhomologous repair processes. Many of these pathways compete actively for the repair of a double-strand break. Which of these repair pathways is used appears to be regulated developmentally, genetically and during the cell cycle.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Recombination, Genetic
/
DNA
/
DNA Repair
Limits:
Animals
Language:
En
Journal:
Trends Genet
Journal subject:
GENETICA
Year:
2000
Type:
Article
Affiliation country:
United States