Altered activity of MDR-reversing agents on KB3-1 cells transfected with Gly(185)-->Val human P-glycoprotein.

Watanabe, T; Uchiyama, N; Roninson, I B; Cohen, D; Atadja, P

Watanabe, T; Uchiyama, N; Roninson, I B; Cohen, D; Atadja, P.

Affiliation

Watanabe T; Novartis Pharma K.K., Tsukuba Research Institute, Ibaraki, Japan.

Int J Oncol ; 17(3): 579-86, 2000 Sep.

Article in En | MEDLINE | ID: mdl-10938401

Subject(s)

ATP Binding Cassette Transporter, Subfamily B, Member 1/genetics; Amino Acid Substitution; Antineoplastic Agents/metabolism; Cyclosporine/pharmacology; Cyclosporins/pharmacology; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Neoplasm Proteins/genetics; ATP Binding Cassette Transporter, Subfamily B, Member 1/chemistry; ATP Binding Cassette Transporter, Subfamily B, Member 1/physiology; Adenosine Triphosphatases/metabolism; Biological Transport, Active/drug effects; Calcium Channel Blockers/pharmacology; Carcinoma, Squamous Cell/pathology; Colchicine/metabolism; Daunorubicin/metabolism; Humans; Neoplasm Proteins/chemistry; Neoplasm Proteins/physiology; Paclitaxel/metabolism; Point Mutation; Structure-Activity Relationship; Transfection; Tumor Cells, Cultured/drug effects; Tumor Cells, Cultured/metabolism; Verapamil/pharmacology; Vinblastine/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Cyclosporine / ATP Binding Cassette Transporter, Subfamily B, Member 1 / Drug Resistance, Multiple / Drug Resistance, Neoplasm / Amino Acid Substitution / Cyclosporins / Neoplasm Proteins / Antineoplastic Agents Limits: Humans Language: En Journal: Int J Oncol Journal subject: NEOPLASIAS Year: 2000 Type: Article Affiliation country: Japan

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