CoMFA-based prediction of agonist affinities at recombinant wild type versus serine to alanine point mutated D2 dopamine receptors.

Wilcox, R E; Huang, W H; Brusniak, M Y; Wilcox, D M; Pearlman, R S; Teeter, M M; DuRand, C J; Wiens, B L; Neve, K A

Wilcox, R E; Huang, W H; Brusniak, M Y; Wilcox, D M; Pearlman, R S; Teeter, M M; DuRand, C J; Wiens, B L; Neve, K A.

Affiliation

Wilcox RE; Molecular Pharmacology Laboratory, College of Pharmacy, and Institute for Neuroscience, University of Texas, Austin, Texas 78712, USA. wilcoxrich@mail.utexas.edu

J Med Chem ; 43(16): 3005-19, 2000 Aug 10.

Article in En | MEDLINE | ID: mdl-10956209

Subject(s)

Alanine/genetics; Dopamine Agonists/chemistry; Receptors, Dopamine D2/chemistry; Serine/genetics; Amino Acid Substitution; Animals; Bromocriptine/chemistry; Combinatorial Chemistry Techniques; Dopamine Agonists/chemical synthesis; Dopamine Agonists/metabolism; Models, Molecular; Pergolide/chemistry; Point Mutation; Radioligand Assay; Rats; Receptors, Dopamine D2/genetics; Receptors, Dopamine D2/metabolism; Recombinant Proteins/chemistry; Recombinant Proteins/genetics; Recombinant Proteins/metabolism; Structure-Activity Relationship; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Serine / Receptors, Dopamine D2 / Dopamine Agonists / Alanine Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2000 Type: Article Affiliation country: United States

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