Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation.

Shan, X; Czar, M J; Bunnell, S C; Liu, P; Liu, Y; Schwartzberg, P L; Wange, R L

Shan, X; Czar, M J; Bunnell, S C; Liu, P; Liu, Y; Schwartzberg, P L; Wange, R L.

Affiliation

Shan X; Laboratory of Biological Chemistry, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224-6825, USA.

Mol Cell Biol ; 20(18): 6945-57, 2000 Sep.

Article in En | MEDLINE | ID: mdl-10958690

Subject(s)

CD3 Complex/metabolism; Phosphoric Monoester Hydrolases/physiology; Protein-Tyrosine Kinases/metabolism; T-Lymphocytes/metabolism; Tumor Suppressor Proteins; Animals; Antigens, Polyomavirus Transforming/genetics; Base Sequence; Binding Sites; Biological Transport; Blood Proteins/metabolism; CD3 Complex/pharmacology; Cell Membrane/metabolism; Cytosol; Enzyme Activation; Exons; Humans; Isoenzymes/metabolism; Jurkat Cells; Molecular Sequence Data; Mutagenesis; PTEN Phosphohydrolase; Phosphatidylinositol 3-Kinases/metabolism; Phosphatidylinositol Phosphates/metabolism; Phospholipase C gamma; Phosphoproteins/metabolism; Phosphoric Monoester Hydrolases/biosynthesis; Phosphoric Monoester Hydrolases/genetics; Phosphorylation; Protein Serine-Threonine Kinases/metabolism; Protein Tyrosine Phosphatases/metabolism; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins c-akt; Rabbits; T-Lymphocytes/drug effects; T-Lymphocytes/immunology; Transcription, Genetic; Tumor Cells, Cultured; Type C Phospholipases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein-Tyrosine Kinases / T-Lymphocytes / CD3 Complex / Phosphoric Monoester Hydrolases / Tumor Suppressor Proteins Type of study: Etiology_studies Language: En Journal: Mol Cell Biol Year: 2000 Type: Article Affiliation country: United States

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