Premorbid functioning versus duration of untreated psychosis in 1 year outcome in first-episode psychosis.
Schizophr Res
; 45(1-2): 1-9, 2000 Sep 29.
Article
in En
| MEDLINE
| ID: mdl-10978867
ABSTRACT
OBJECTIVE:
This study examines 1year outcome in patients having first-episode non-affective psychosis, with emphasis on Duration of Untreated Psychosis (DUP) and premorbid functioning, in order to clarify how these factors interact.METHOD:
Forty-three consecutively admitted patients were all rated on the Positive and Negative Syndrome Scale (PANSS) and the Global Assessment of Functioning Scale (GAF), both upon hospitalization and at 1year follow-up. In addition, premorbid functioning, DUP, duration of hospitalization, and social functioning were rated.RESULTS:
Fifty-six per cent were in remission, 18% suffered multiple relapses and 26% were continuously psychotic at 1 year follow-up. Both poor premorbid functioning and long DUP are significantly correlated with more negative symptoms and poorer global functioning at follow-up. Long DUP is also significantly correlated with more positive symptoms. Even when we control for other factors, including premorbid functioning and gender, DUP is a strong predictor of outcome. To a limited degree premorbid functioning and DUP interact, but DUP has an independent influence on outcome.CONCLUSIONS:
these findings strengthen the rationale for establishing health service programs for early detection and treatment of first-onset psychosis
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Psychotic Disorders
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Schizophr Res
Journal subject:
PSIQUIATRIA
Year:
2000
Type:
Article
Affiliation country:
Norway