Inhibition of ornithine decarboxylase (ODC) decreases tumor vascularization and reverses spontaneous tumors in ODC/Ras transgenic mice.

Lan, L; Trempus, C; Gilmour, S K

Lan, L; Trempus, C; Gilmour, S K.

Affiliation

Lan L; The Lankenau Institute for Medical Research, Wynnewood, Pennsylvania 19096, USA.

Cancer Res ; 60(20): 5696-703, 2000 Oct 15.

Article in En | MEDLINE | ID: mdl-11059762

Subject(s)

Genes, ras/genetics; Neovascularization, Pathologic/enzymology; Ornithine Decarboxylase Inhibitors; Skin Neoplasms/blood supply; Skin Neoplasms/prevention & control; Animals; Antineoplastic Agents/pharmacology; Cell Differentiation/drug effects; Cell Division/drug effects; Crosses, Genetic; Eflornithine/pharmacology; Enzyme Inhibitors/pharmacology; Female; Gene Expression/drug effects; In Situ Hybridization; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neovascularization, Pathologic/drug therapy; Neovascularization, Pathologic/prevention & control; Ornithine Decarboxylase/biosynthesis; Ornithine Decarboxylase/genetics; RNA, Messenger/biosynthesis; RNA, Messenger/genetics; Skin Neoplasms/enzymology; Skin Neoplasms/pathology; Transgenes

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Collection: 01-internacional Database: MEDLINE Main subject: Skin Neoplasms / Genes, ras / Ornithine Decarboxylase Inhibitors / Neovascularization, Pathologic Limits: Animals Language: En Journal: Cancer Res Year: 2000 Type: Article Affiliation country: United States

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