In vitro sensitivity of T-cell lymphoblastic leukemia to UCN-01 (7-hydroxystaurosporine) is dependent on p16 protein status: a Pediatric Oncology Group study.

Omura-Minamisawa, M; Diccianni, M B; Batova, A; Chang, R C; Bridgeman, L J; Yu, J; de Wit, E; Kung, F H; Pullen, J D; Yu, A L

Omura-Minamisawa, M; Diccianni, M B; Batova, A; Chang, R C; Bridgeman, L J; Yu, J; de Wit, E; Kung, F H; Pullen, J D; Yu, A L.

Affiliation

Omura-Minamisawa M; Department of Pediatrics/Hematology-Oncology, University of California, San Diego 92103-8447, USA.

Cancer Res ; 60(23): 6573-6, 2000 Dec 01.

Article in En | MEDLINE | ID: mdl-11118035

Subject(s)

Alkaloids/toxicity; Antineoplastic Agents/toxicity; Cell Cycle Proteins; Cyclin-Dependent Kinase Inhibitor p16/physiology; Leukemia-Lymphoma, Adult T-Cell/drug therapy; Tumor Suppressor Proteins; Carrier Proteins/biosynthesis; Carrier Proteins/genetics; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p16/biosynthesis; Cyclin-Dependent Kinase Inhibitor p16/genetics; Gene Deletion; Gene Expression Regulation, Leukemic; Gene Silencing; Humans; Leukemia-Lymphoma, Adult T-Cell/genetics; Leukemia-Lymphoma, Adult T-Cell/metabolism; Phosphorylation; Retinoblastoma Protein/biosynthesis; Retinoblastoma Protein/genetics; Retinoblastoma Protein/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Staurosporine/analogs & derivatives; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Leukemia-Lymphoma, Adult T-Cell / Cell Cycle Proteins / Cyclin-Dependent Kinase Inhibitor p16 / Tumor Suppressor Proteins / Alkaloids / Antineoplastic Agents Type of study: Diagnostic_studies Limits: Humans Language: En Journal: Cancer Res Year: 2000 Type: Article Affiliation country: United States

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