Tensile stress induces bone morphogenetic protein 4 in preosteoblastic and fibroblastic cells, which later differentiate into osteoblasts leading to osteogenesis in the mouse calvariae in organ culture.

Ikegame, M; Ishibashi, O; Yoshizawa, T; Shimomura, J; Komori, T; Ozawa, H; Kawashima, H

Ikegame, M; Ishibashi, O; Yoshizawa, T; Shimomura, J; Komori, T; Ozawa, H; Kawashima, H.

Affiliation

Ikegame M; Department of Pharmacology, Niigata University, Niigata-City, Japan.

J Bone Miner Res ; 16(1): 24-32, 2001 Jan.

Article in En | MEDLINE | ID: mdl-11149486

Subject(s)

Bone Morphogenetic Proteins/genetics; Gene Expression Regulation; Neoplasm Proteins; Osteoblasts/cytology; Osteoblasts/metabolism; Osteogenesis; Skull/metabolism; Alkaline Phosphatase/metabolism; Animals; Animals, Newborn; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins/metabolism; Cell Count; Cell Differentiation; Core Binding Factor Alpha 1 Subunit; Fibroblasts/metabolism; Histocytochemistry; In Situ Hybridization; Mice; Organ Culture Techniques; RNA, Messenger/genetics; RNA, Messenger/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Skull/cytology; Stem Cells/cytology; Stem Cells/metabolism; Stress, Mechanical; Transcription Factors/genetics; Transcription Factors/metabolism; Up-Regulation

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Collection: 01-internacional Database: MEDLINE Main subject: Osteoblasts / Osteogenesis / Skull / Gene Expression Regulation / Bone Morphogenetic Proteins / Neoplasm Proteins Limits: Animals Language: En Journal: J Bone Miner Res Journal subject: METABOLISMO / ORTOPEDIA Year: 2001 Type: Article Affiliation country: Japan

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