Protective effect of erdosteine against hypochlorous acid-induced acute lung injury and lipopolysaccharide-induced neutrophilic lung inflammation in mice.

Hayashi, K; Hosoe, H; Kaise, T; Ohmori, K

Hayashi, K; Hosoe, H; Kaise, T; Ohmori, K.

Affiliation

Hayashi K; Drug Development Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd, Shizuoka, Japan.

J Pharm Pharmacol ; 52(11): 1411-6, 2000 Nov.

Article in En | MEDLINE | ID: mdl-11186250

Subject(s)

Bronchitis/drug therapy; Expectorants/pharmacology; Lung/pathology; Thioglycolates/pharmacology; Thiophenes/pharmacology; Tumor Necrosis Factor-alpha/biosynthesis; Administration, Oral; Animals; Bronchoalveolar Lavage Fluid/chemistry; Chronic Disease; Disease Models, Animal; Hypochlorous Acid/administration & dosage; Hypochlorous Acid/adverse effects; Inflammation; Lipopolysaccharides/administration & dosage; Lipopolysaccharides/adverse effects; Lung/drug effects; Male; Mice; Mice, Inbred BALB C; Reactive Oxygen Species

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Collection: 01-internacional Database: MEDLINE Main subject: Thioglycolates / Thiophenes / Bronchitis / Tumor Necrosis Factor-alpha / Expectorants / Lung Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Pharm Pharmacol Year: 2000 Type: Article Affiliation country: Japan

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