Aspirin, but not the more selective cyclooxygenase (COX)-2 inhibitors meloxicam and SC 58125, aggravates postischaemic cardiac dysfunction, independent of COX function.

Heindl, B; Becker, B F

Heindl, B; Becker, B F.

Affiliation

Heindl B; Department of Physiology, University of Munich, Germany. heindl@ana.med.uni-muenchen.de

Naunyn Schmiedebergs Arch Pharmacol ; 363(2): 233-40, 2001 Feb.

Article in En | MEDLINE | ID: mdl-11218076

Subject(s)

Aspirin/pharmacology; Cyclooxygenase Inhibitors/pharmacology; Heart/drug effects; Isoenzymes/antagonists & inhibitors; Myocardial Ischemia/metabolism; Myocardial Reperfusion Injury/metabolism; Thiazines/pharmacology; Thiazoles/pharmacology; Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprost/analogs & derivatives; Dinoprost/analysis; Eicosanoids/metabolism; F2-Isoprostanes; Guinea Pigs; Heart/physiology; Hemodynamics/drug effects; Hemodynamics/physiology; Male; Meloxicam; Prostaglandin-Endoperoxide Synthases; Pyrazoles/pharmacology; Thromboxane A2/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Thiazines / Thiazoles / Myocardial Reperfusion Injury / Aspirin / Cyclooxygenase Inhibitors / Myocardial Ischemia / Heart / Isoenzymes Limits: Animals Language: En Journal: Naunyn Schmiedebergs Arch Pharmacol Year: 2001 Type: Article Affiliation country: Germany

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