Interleukin-18 (IL-18) synergizes with IL-2 to enhance cytotoxicity, interferon-gamma production, and expansion of natural killer cells.

Son, Y I; Dallal, R M; Mailliard, R B; Egawa, S; Jonak, Z L; Lotze, M T

Son, Y I; Dallal, R M; Mailliard, R B; Egawa, S; Jonak, Z L; Lotze, M T.

Affiliation

Son YI; Department of Surgery, University of Pittsburgh Cancer Institute, Pennsylvania 15261, USA.

Cancer Res ; 61(3): 884-8, 2001 Feb 01.

Article in En | MEDLINE | ID: mdl-11221875

Subject(s)

Interferon-gamma/biosynthesis; Interleukin-18/pharmacology; Interleukin-2/pharmacology; Killer Cells, Natural/immunology; CD4-Positive T-Lymphocytes/drug effects; CD4-Positive T-Lymphocytes/immunology; CD4-Positive T-Lymphocytes/metabolism; CD8-Positive T-Lymphocytes/drug effects; CD8-Positive T-Lymphocytes/immunology; CD8-Positive T-Lymphocytes/metabolism; Cell Division/drug effects; Cytotoxicity, Immunologic/drug effects; Drug Synergism; Humans; Killer Cells, Natural/drug effects; Killer Cells, Natural/metabolism; Leukocytes, Mononuclear/drug effects; Leukocytes, Mononuclear/immunology; Leukocytes, Mononuclear/metabolism; Lymphocyte Activation/drug effects; Lymphocytes/drug effects; Lymphocytes/immunology; Lymphocytes/metabolism; Lymphoma, B-Cell/immunology; Receptors, Interleukin-2/biosynthesis; Tumor Cells, Cultured; Up-Regulation/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Killer Cells, Natural / Interferon-gamma / Interleukin-2 / Interleukin-18 Limits: Humans Language: En Journal: Cancer Res Year: 2001 Type: Article Affiliation country: United States

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