SJL and NOD macrophages are uniquely characterized by genetically programmed, elevated expression of the IL-12(p40) gene, suggesting a conserved pathway for the induction of organ-specific autoimmunity.

Alleva, D G; Johnson, E B; Wilson, J; Beller, D I; Conlon, P J

Alleva, D G; Johnson, E B; Wilson, J; Beller, D I; Conlon, P J.

Affiliation

Alleva DG; Neurocrine Biosciences, Inc., San Diego, California 92121-1102, USA. dalleva@neurocrine.com

J Leukoc Biol ; 69(3): 440-8, 2001 Mar.

Article in En | MEDLINE | ID: mdl-11261792

Subject(s)

Encephalomyelitis, Autoimmune, Experimental/genetics; Interleukin-12/biosynthesis; Interleukin-12/genetics; Macrophages, Peritoneal/physiology; Animals; Antigen-Presenting Cells/immunology; Antigen-Presenting Cells/metabolism; Antigen-Presenting Cells/physiology; Autoimmunity/genetics; CD40 Ligand/pharmacology; Dimerization; Encephalomyelitis, Autoimmune, Experimental/immunology; Encephalomyelitis, Autoimmune, Experimental/metabolism; Gene Expression Regulation; Genetic Predisposition to Disease; Interferon-gamma/pharmacology; Macrophage Activation/drug effects; Macrophage Activation/physiology; Macrophages, Peritoneal/immunology; Macrophages, Peritoneal/metabolism; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred NOD; Organ Specificity

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Collection: 01-internacional Database: MEDLINE Main subject: Macrophages, Peritoneal / Interleukin-12 / Encephalomyelitis, Autoimmune, Experimental Limits: Animals Language: En Journal: J Leukoc Biol Year: 2001 Type: Article Affiliation country: United States

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