Thymidine kinase, thymidylate synthase, and dihydropyrimidine dehydrogenase profiles of cell lines of the National Cancer Institute's Anticancer Drug Screen.

Grem, J L; Danenberg, K D; Behan, K; Parr, A; Young, L; Danenberg, P V; Nguyen, D; Drake, J; Monks, A; Allegra, C J

Grem, J L; Danenberg, K D; Behan, K; Parr, A; Young, L; Danenberg, P V; Nguyen, D; Drake, J; Monks, A; Allegra, C J.

Affiliation

Grem JL; Developmental Therapeutics Department, Medicine Branch, Division of Clinical Sciences, National Cancer Institute at the National Naval Medical Center, Bethesda, Maryland 20889, USA.

Clin Cancer Res ; 7(4): 999-1009, 2001 Apr.

Article in En | MEDLINE | ID: mdl-11309351

Subject(s)

Antimetabolites, Antineoplastic/pharmacology; Floxuridine/pharmacology; Fluorouracil/pharmacology; Oxidoreductases/metabolism; Thymidine Kinase/metabolism; Thymidylate Synthase/metabolism; Animals; Cell Division/drug effects; Cell Line; DNA/biosynthesis; DNA/drug effects; Databases, Factual; Dihydrouracil Dehydrogenase (NADP); Drug Screening Assays, Antitumor; Humans; Mutation/drug effects; National Institutes of Health (U.S.); Oxidoreductases/genetics; RNA, Messenger/drug effects; RNA, Messenger/metabolism; Thymidine/metabolism; Thymidylate Synthase/genetics; Tumor Cells, Cultured; Tumor Suppressor Protein p53/genetics; United States

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Collection: 01-internacional Database: MEDLINE Main subject: Oxidoreductases / Thymidine Kinase / Thymidylate Synthase / Floxuridine / Fluorouracil / Antimetabolites, Antineoplastic Limits: Animals / Humans Country/Region as subject: America do norte Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2001 Type: Article Affiliation country: United States

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