Retinol supplementation induces oxidative stress and modulates antioxidant enzyme activities in rat sertoli cells.
Free Radic Res
; 34(4): 395-404, 2001 Apr.
Article
in En
| MEDLINE
| ID: mdl-11328675
ABSTRACT
Recent intervention studies revealed that supplementation with retinoids resulted in a higher incidence of lung cancer. Recently the causal mechanism has begun to be clarified. We report here that retinol caused cellular oxidative stress and modulated superoxide dismutase, catalase and glutathione peroxidase activities. Retinol (7 microM) significantly increased TBARS, conjugated dienes, and hydroperoxide-initiated chemiluminescence in cultured Sertoli cells. In response to retinol treatment superoxide dismutase, catalase and glutathione peroxidase activities increased. TBARS content and catalase activities were decreased by a free radical scavenger. These findings suggest that retinol may induce oxidative stress and modulate antioxidant enzyme activities in Sertoli cells.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sertoli Cells
/
Superoxide Dismutase
/
Vitamin A
/
Catalase
/
Oxidative Stress
/
Glutathione Peroxidase
/
Antioxidants
Limits:
Animals
Language:
En
Journal:
Free Radic Res
Journal subject:
BIOQUIMICA
Year:
2001
Type:
Article
Affiliation country:
Brazil