VEGF protects against oxidized LDL toxicity to endothelial cells by an intracellular glutathione-dependent mechanism through the KDR receptor.

Kuzuya, M; Ramos, M A; Kanda, S; Koike, T; Asai, T; Maeda, K; Shitara, K; Shibuya, M; Iguchi, A

Kuzuya, M; Ramos, M A; Kanda, S; Koike, T; Asai, T; Maeda, K; Shitara, K; Shibuya, M; Iguchi, A.

Affiliation

Kuzuya M; Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan. kuzuya@med.nagoya-u.ac.jp

Arterioscler Thromb Vasc Biol ; 21(5): 765-70, 2001 May.

Article in En | MEDLINE | ID: mdl-11348872

Subject(s)

Endothelial Growth Factors/pharmacology; Endothelium, Vascular/drug effects; Glutathione/metabolism; Lipoproteins, LDL/toxicity; Lymphokines/pharmacology; Receptor Protein-Tyrosine Kinases/metabolism; Receptors, Growth Factor/metabolism; Animals; Antibodies/immunology; Arteriosclerosis/metabolism; Cattle; Cells, Cultured; Endothelium, Vascular/metabolism; Enzyme Inhibitors/pharmacology; L-Lactate Dehydrogenase/metabolism; NG-Nitroarginine Methyl Ester/pharmacology; Nitric Oxide/antagonists & inhibitors; Oxidation-Reduction; Receptor Protein-Tyrosine Kinases/immunology; Receptors, Growth Factor/immunology; Receptors, Vascular Endothelial Growth Factor; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Endothelium, Vascular / Endothelial Growth Factors / Lymphokines / Receptors, Growth Factor / Receptor Protein-Tyrosine Kinases / Glutathione / Lipoproteins, LDL Limits: Animals Language: En Journal: Arterioscler Thromb Vasc Biol Journal subject: ANGIOLOGIA Year: 2001 Type: Article Affiliation country: Japan

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