Synthesis, pharmacological characterization and QSAR studies on 2-substituted indole melatonin receptor ligands.

Mor, M; Spadoni, G; Di Giacomo, B; Diamantini, G; Bedini, A; Tarzia, G; Plazzi, P V; Rivara, S; Nonno, R; Lucini, V; Pannacci, M; Fraschini, F; Stankov, B M

Mor, M; Spadoni, G; Di Giacomo, B; Diamantini, G; Bedini, A; Tarzia, G; Plazzi, P V; Rivara, S; Nonno, R; Lucini, V; Pannacci, M; Fraschini, F; Stankov, B M.

Affiliation

Mor M; Dipartimento Farmaceutico, Università degli Studi di Parma, Italy.

Bioorg Med Chem ; 9(4): 1045-57, 2001 Apr.

Article in En | MEDLINE | ID: mdl-11354661

Subject(s)

Indoles/chemical synthesis; Indoles/pharmacology; Melatonin/metabolism; Receptors, Cell Surface/drug effects; Receptors, Cytoplasmic and Nuclear/drug effects; 3T3 Cells; Algorithms; Animals; Guanosine 5'-O-(3-Thiotriphosphate)/pharmacology; Humans; Least-Squares Analysis; Ligands; Melatonin/analogs & derivatives; Mice; Models, Molecular; Protein Conformation; Quantitative Structure-Activity Relationship; Receptors, Melatonin; Regression Analysis

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Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Cytoplasmic and Nuclear / Receptors, Cell Surface / Indoles / Melatonin Type of study: Diagnostic_studies Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2001 Type: Article Affiliation country: Italy

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