The potential role of interleukin-2 in HIV.
AIDS
; 15 Suppl 2: S22-7, 2001 Feb.
Article
in En
| MEDLINE
| ID: mdl-11424973
ABSTRACT
Interleukin-2 (IL-2) is a secretory cytokine produced by activated T cells that stimulates T cells, B cells, and natural killer cells to proliferate and release cytokines. In addition, IL-2 slows apoptosis of HIV-infected cells. Clinical studies have demonstrated that exogenous human recombinant IL-2 can be safely administered concurrently with potent antiretroviral therapy to HIV-infected patients. It was further demonstrated that recombinant human IL-2 therapy produces sustained increases in CD4+ cell number and function in patients with both early and late HIV disease. Further evaluation of the clinical efficacy of IL-2 in HIV-infected patients is expected to provide important information on the utility of recombinant human IL-2 in HIV disease.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
HIV Infections
/
HIV
/
Interleukin-2
/
Anti-HIV Agents
Limits:
Humans
Language:
En
Journal:
AIDS
Journal subject:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Year:
2001
Type:
Article
Affiliation country:
United States