A highly aggressive primitive mesenchymal tumor with a translocation (1;19)(q12;q13.2).
Cancer Genet Cytogenet
; 127(2): 128-33, 2001 Jun.
Article
in En
| MEDLINE
| ID: mdl-11425451
ABSTRACT
Soft tissue sarcomas constitute a heterogeneous group of malignant tumors of mesenchymal origin, the classification of which may present a diagnostic challenge. We present here the cytological, histopathological, immunohistochemical, and cytogenetic findings of an unusual case of a highly aggressive sarcoma. Based on the morphology and the immunohistochemical profile, this primitive tumor and its metastases could not be conclusively classified as any of the defined subtypes of sarcomas, although the findings were suggestive of a variant of rhabdomyosarcoma. Cytogenetic characterization using G-banding, SKY, FISH, and CGH revealed almost identical chromosomal compositions of the primary tumor and the metastasis. The hypertetraploid karyotype was characterized by numerical imbalances as well as by an unbalanced translocation t(1;19)(q12;q13.2), which has not been previously reported.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Translocation, Genetic
/
Chromosomes, Human, Pair 1
/
Chromosomes, Human, Pair 19
/
Mesenchymoma
Type of study:
Diagnostic_studies
Limits:
Humans
/
Male
/
Middle aged
Country/Region as subject:
Europa
Language:
En
Journal:
Cancer Genet Cytogenet
Year:
2001
Type:
Article
Affiliation country:
Sweden