The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound.

Briejer, M R; Bosmans, J P; Van Daele, P; Jurzak, M; Heylen, L; Leysen, J E; Prins, N H; Schuurkes, J A

Briejer, M R; Bosmans, J P; Van Daele, P; Jurzak, M; Heylen, L; Leysen, J E; Prins, N H; Schuurkes, J A.

Affiliation

Briejer MR; Department of Gastrointestinal Pharmacology, Janssen Research Foundation, Turnhoutseweg 30, 2340 Beerse, Belgium.

Eur J Pharmacol ; 423(1): 71-83, 2001 Jun 29.

Article in En | MEDLINE | ID: mdl-11438309

Subject(s)

Benzofurans/pharmacology; Gastrointestinal Agents/pharmacology; Acetylcholine/pharmacology; Animals; Benzofurans/metabolism; Binding, Competitive; CHO Cells; Carbachol/pharmacology; Cell Line; Colon/drug effects; Colon/physiology; Cricetinae; Dioxanes/pharmacology; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Esophagus/drug effects; Esophagus/physiology; Female; Gallbladder/drug effects; Gallbladder/physiology; Gastrointestinal Agents/metabolism; Granisetron/pharmacology; Guinea Pigs; Humans; Ileum/drug effects; Ileum/physiology; In Vitro Techniques; Indoles/pharmacology; Indomethacin/pharmacology; Male; Motilin/analogs & derivatives; Motilin/pharmacology; Muscle Contraction/drug effects; Piperidines/pharmacology; Rabbits; Rats; Rats, Wistar; Receptors, Cholecystokinin/antagonists & inhibitors; Receptors, Dopamine D2/metabolism; Receptors, Dopamine D4; Receptors, Gastrointestinal Hormone/antagonists & inhibitors; Receptors, Neuropeptide/antagonists & inhibitors; Receptors, Serotonin/metabolism; Serotonin/pharmacology; Serotonin Antagonists/pharmacology; Serotonin Receptor Agonists/metabolism; Serotonin Receptor Agonists/pharmacology; Sincalide/pharmacology; Stomach/drug effects; Stomach/physiology; Sulfonamides/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Benzofurans / Gastrointestinal Agents Type of study: Guideline Language: En Journal: Eur J Pharmacol Year: 2001 Type: Article Affiliation country: Belgium

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