Influence of amiodarone on urinary excretion of 6beta-hydroxycortisol in humans.
Physiol Res
; 50(2): 191-6, 2001.
Article
in En
| MEDLINE
| ID: mdl-11522047
ABSTRACT
The present study was undertaken to evaluate the use of cortisol 6beta-hydroxylation in defining the effect of amiodarone on cytochrome CYP3A activity. To accomplish this goal, the in vivo activity of CYP3A was estimated by measuring the 24-hour urinary excretion of 6beta-hydroxycortisol (6beta-OHC) and by calculating 24-hour ratio of 6beta-hydroxycortisol to urinary free cortisol (6beta-OHC/UFC ratio). Nine cardiac patients scheduled for amiodarone treatment were recruited to participate in this study. Urine was collected over a 24-hour period from each subject before the first amiodarone administration and during the third day of oral administration of amiodarone (200 mg four times daily as a loading dose). Three days of amiodarone treatment caused a significant decrease (p<0.05) in both the 6beta-OHC/UFC ratio and the 24-hour urinary excretion of 6beta3-OHC. These results suggest that amiodarone is an inhibitor of CYP3A activity.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Vasodilator Agents
/
Hydrocortisone
/
Aryl Hydrocarbon Hydroxylases
/
Myocardial Ischemia
/
Amiodarone
Limits:
Adult
/
Aged
/
Humans
/
Middle aged
Language:
En
Journal:
Physiol Res
Journal subject:
FISIOLOGIA
Year:
2001
Type:
Article
Affiliation country:
Czech Republic