[Decreased frequency of activation of replicon clusters in Down syndrome lymphocytes]. / Ponizhennaia chastota aktivatsii klasterov replikonov v limfotsitakh pri sindrome Dauna.
Tsitologiia
; 43(7): 692-7, 2001.
Article
in Ru
| MEDLINE
| ID: mdl-11552652
ABSTRACT
Human blood lymphocytes from two normal and seven Down syndrome (DS) subjects were examined to determine rates of synthesis of individual replicon and adjacent clusters of replicons, using DNA fiber autoradiography. Lymphocytes in 6 of 7 DS patients were shown to have significantly slower synthesis of simultaneously active adjacent replicon clusters compared to normal controls. Rates of synthesis of individual replicons were the same in lymphocytes from all the subjects investigated. These results demonstrate differences in respect to the structural organization of clusters of replicons between DS and normal lymphocytes. A possible relation of the above phenomenon to the chromosomal radiosensitivity in DS cells is discussed.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Replicon
/
Lymphocytes
/
Down Syndrome
Type of study:
Observational_studies
Limits:
Humans
Language:
Ru
Journal:
Tsitologiia
Year:
2001
Type:
Article