Breast Neoplasms/prevention & control; Coronary Disease/prevention & control; Osteoporosis/prevention & control; Selective Estrogen Receptor Modulators/therapeutic use; Adult; Aged; Bone and Bones/drug effects; Breast/drug effects; Breast Neoplasms/chemistry; Breast Neoplasms/epidemiology; Cardiovascular System/drug effects; Cinnamates/pharmacology; Clinical Trials as Topic; Coronary Disease/epidemiology; Endometrial Neoplasms/chemically induced; Estrogen Replacement Therapy; Female; Heart/drug effects; Hot Flashes/chemically induced; Humans; Middle Aged; Models, Biological; Organ Specificity; Osteoporosis/epidemiology; Postmenopause; Premenopause; Prospective Studies; Protein Structure, Tertiary/drug effects; Raloxifene Hydrochloride/adverse effects; Raloxifene Hydrochloride/pharmacology; Raloxifene Hydrochloride/therapeutic use; Randomized Controlled Trials as Topic; Receptors, Estrogen/analysis; Receptors, Estrogen/drug effects; Risk; Risk Assessment; Selective Estrogen Receptor Modulators/adverse effects; Selective Estrogen Receptor Modulators/pharmacology; Stilbenes/pharmacology; Tamoxifen/adverse effects; Tamoxifen/pharmacology; Tamoxifen/therapeutic use; Thrombophilia/chemically induced; Transcription, Genetic/drug effects