Oxindole derivatives as orally active potent growth hormone secretagogues.

Tokunaga, T; Hume, W E; Umezome, T; Okazaki, K; Ueki, Y; Kumagai, K; Hourai, S; Nagamine, J; Seki, H; Taiji, M; Noguchi, H; Nagata, R

Tokunaga, T; Hume, W E; Umezome, T; Okazaki, K; Ueki, Y; Kumagai, K; Hourai, S; Nagamine, J; Seki, H; Taiji, M; Noguchi, H; Nagata, R.

Affiliation

Tokunaga T; Research Division, Sumitomo Pharmaceuticals Co., Ltd, 1-98 Kasugadenaka 3-chome, Konohana-ku, Osaka 554-0022, Japan.

J Med Chem ; 44(26): 4641-9, 2001 Dec 20.

Article in En | MEDLINE | ID: mdl-11741481

Subject(s)

Ethylamines/chemical synthesis; Growth Hormone/metabolism; Indoles/chemical synthesis; Receptors, G-Protein-Coupled; Administration, Oral; Animals; Biological Availability; Body Weight/drug effects; CHO Cells; Cricetinae; Crystallography, X-Ray; Ethylamines/chemistry; Ethylamines/pharmacology; Female; Human Growth Hormone/metabolism; Humans; In Vitro Techniques; Indoles/chemistry; Indoles/pharmacology; Male; Models, Molecular; Molecular Conformation; Pituitary Gland, Anterior/cytology; Pituitary Gland, Anterior/metabolism; Rats; Rats, Inbred F344; Rats, Wistar; Receptors, Cell Surface/metabolism; Receptors, Ghrelin; Stereoisomerism; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Growth Hormone / Receptors, G-Protein-Coupled / Ethylamines / Indoles Limits: Animals / Female / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2001 Type: Article Affiliation country: Japan

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