Modulation of cisplatin pharmacodynamics by Cremophor EL: experimental and clinical studies.

Gelderblom, H; Loos, W J; Verweij, J; van der Burg, M E L; de Jonge, M J A; Brouwer, E; Nooter, K; Stoter, G; Sparreboom, A

Gelderblom, H; Loos, W J; Verweij, J; van der Burg, M E L; de Jonge, M J A; Brouwer, E; Nooter, K; Stoter, G; Sparreboom, A.

Affiliation

Gelderblom H; Department of Medical Oncology, Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, 3075 EA Rotterdam, The Netherlands. a.j.gelderblom@lumc.nl

Eur J Cancer ; 38(1): 205-13, 2002 Jan.

Article in En | MEDLINE | ID: mdl-11750851

Subject(s)

Antineoplastic Agents/pharmacokinetics; Cisplatin/pharmacokinetics; Glycerol/analogs & derivatives; Glycerol/pharmacology; Hematologic Diseases/chemically induced; Ovarian Neoplasms/metabolism; Pharmaceutical Vehicles/pharmacology; Animals; Antineoplastic Agents/administration & dosage; Antineoplastic Agents/adverse effects; Cisplatin/administration & dosage; Cisplatin/adverse effects; Dose-Response Relationship, Drug; Drug Interactions; Female; Hematologic Diseases/prevention & control; Humans; Infusions, Intravenous; Infusions, Parenteral; Mice; Neoplasm Recurrence, Local/drug therapy; Neoplasm Recurrence, Local/metabolism; Ovarian Neoplasms/drug therapy

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Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Pharmaceutical Vehicles / Cisplatin / Glycerol / Hematologic Diseases / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Eur J Cancer Year: 2002 Type: Article Affiliation country: Netherlands

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