The synthesis and selective IL-2 inhibitory activity of bis piperazine-phenol Mannich adducts.

Geng, Bolin; Fleming, Paul R; Umlauf, Scott; Lin, Augustine; Pallai, Peter V

Geng, Bolin; Fleming, Paul R; Umlauf, Scott; Lin, Augustine; Pallai, Peter V.

Affiliation

Geng B; ArQule, Inc., 19 Presidential Way, Woburn, MA 01801, USA. bgeng@arqule.com

Bioorg Med Chem Lett ; 12(5): 775-8, 2002 Mar 11.

Article in En | MEDLINE | ID: mdl-11859000

Subject(s)

Interleukin-2/antagonists & inhibitors; Mannich Bases/chemistry; Phenols/chemistry; Piperazines/chemical synthesis; Piperazines/pharmacology; Actins/genetics; Actins/metabolism; DNA Adducts/chemistry; Humans; Inhibitory Concentration 50; Jurkat Cells/drug effects; Luciferases/metabolism; Promoter Regions, Genetic

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Collection: 01-internacional Database: MEDLINE Main subject: Phenols / Piperazines / Interleukin-2 / Mannich Bases Type of study: Prognostic_studies Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2002 Type: Article Affiliation country: United States

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