Suppression of lymphoma and epithelial malignancies effected by interferon gamma.
J Exp Med
; 196(1): 129-34, 2002 Jul 01.
Article
in En
| MEDLINE
| ID: mdl-12093877
ABSTRACT
The immunosurveillance of transformed cells by the immune system remains one of the most controversial and poorly understood areas of immunity. Gene-targeted mice have greatly aided our understanding of the key effector molecules in tumor immunity. Herein, we describe spontaneous tumor development in gene-targeted mice lacking interferon (IFN)-gamma and/or perforin (pfp), or the immunoregulatory cytokines, interleukin (IL)-12, IL-18, and tumor necrosis factor (TNF). Both IFN-gamma and pfp were critical for suppression of lymphomagenesis, however the level of protection afforded by IFN-gamma was strain specific. Lymphomas arising in IFN-gamma-deficient mice were very nonimmunogenic compared with those derived from pfp-deficient mice, suggesting a comparatively weaker immunoselection pressure by IFN-gamma. Single loss of IL-12, IL-18, or TNF was not sufficient for spontaneous tumor development. A significant incidence of late onset adenocarcinoma observed in both IFN-gamma- and pfp-deficient mice indicated that some epithelial tissues were also subject to immunosurveillance.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sarcoma
/
Adenocarcinoma
/
Interferon-gamma
/
Immunologic Surveillance
/
Lung Neoplasms
/
Lymphoma
Limits:
Animals
Language:
En
Journal:
J Exp Med
Year:
2002
Type:
Article
Affiliation country:
Australia