Imidazo[2,1-i]purin-5-ones and related tricyclic water-soluble purine derivatives: potent A(2A)- and A(3)-adenosine receptor antagonists.

Müller, Christa E; Thorand, Mark; Qurishi, Ramatullah; Diekmann, Martina; Jacobson, Kenneth A; Padgett, William L; Daly, John W

Müller, Christa E; Thorand, Mark; Qurishi, Ramatullah; Diekmann, Martina; Jacobson, Kenneth A; Padgett, William L; Daly, John W.

Affiliation

Müller CE; Pharmaceutical Institute Poppelsdorf, University of Bonn, Bonn, Germany. christa.mueller@uni-bonn.de

J Med Chem ; 45(16): 3440-50, 2002 Aug 01.

Article in En | MEDLINE | ID: mdl-12139454

Subject(s)

Heterocyclic Compounds, 3-Ring/chemical synthesis; Imidazoles/chemical synthesis; Purinergic P1 Receptor Antagonists; Purines/chemical synthesis; Purinones/chemical synthesis; 3T3 Cells; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases/biosynthesis; Animals; Brain/drug effects; Brain/metabolism; Electrophoresis, Capillary; Heterocyclic Compounds, 3-Ring/chemistry; Heterocyclic Compounds, 3-Ring/pharmacology; Humans; Imidazoles/chemistry; Imidazoles/pharmacology; In Vitro Techniques; Membranes; Mice; PC12 Cells; Purines/chemistry; Purines/pharmacology; Purinones/chemistry; Purinones/pharmacology; Radioligand Assay; Rats; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Receptor, Adenosine A3; Solubility; Stereoisomerism; Structure-Activity Relationship; Water

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Collection: 01-internacional Database: MEDLINE Main subject: Purines / Purinones / Purinergic P1 Receptor Antagonists / Heterocyclic Compounds, 3-Ring / Imidazoles Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2002 Type: Article Affiliation country: Germany

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