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Clinical outcomes of patients treated with the cutting balloon and Sr-90 beta-irradiation for instent restenosis.
Almeda, Francis Q; Chua, David Y; Nathan, Sandeep; Kim, Susie; Meyer, Peter M; Thew, Stephen T; Nguyen, Cam; Chu, James C H; Kavinsky, Clifford J; Schaer, Gary L; Snell, R Jeffrey.
Affiliation
  • Almeda FQ; Rush Heart Institute, Rush-Presbyterian-St. Luke's Medical Center, 1021 Jelke, 1653 W. Congress Parkway, Chicago, IL 60612, USA. francis_q_almeda@rush.edu
Cardiovasc Radiat Med ; 3(1): 12-5, 2002.
Article in En | MEDLINE | ID: mdl-12479910
ABSTRACT

BACKGROUND:

The cutting balloon (CB) is an emerging therapy for the treatment of instent restenosis (ISR), but its impact on the clinical outcomes of patients treated with intracoronary radiation therapy (IRT) with Sr-90 compared with conventional PTCA and IRT is not clearly defined.

METHODS:

We compared the baseline demographics, angiographic characteristics and clinical outcomes of 102 consecutive patients with ISR treated either with CB+IRT (n=45) or with conventional PTCA+IRT (n=57). The combined endpoint was the occurrence of major adverse cardiac events (MACE), which was defined as a composite of death, myocardial infarction (MI) or target vessel revascularization (TVR) at 6 months.

RESULTS:

The CB+IRT group had a shorter mean lesion length (14.3+/-6.5 vs. 21.1+/-15.7, P=.009), and greater utilization of glycoprotein IIb/IIIa inhibitors during the procedure (48.9% vs. 26.3%, P=.02) compared to the PTCA+IRT group. There were no significant differences in the baseline demographics, angiographic and procedural results, or subsequent MACE at 6 months between the two groups.

CONCLUSION:

The strategy of CB+IRT using Sr-90 for ISR is associated with similar procedural and clinical outcomes compared to conventional PTCA+IRT. Further study is warranted to determine which patient subgroups would derive the most benefit from this approach.
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Collection: 01-internacional Database: MEDLINE Main subject: Strontium Radioisotopes / Beta Particles / Stents / Graft Occlusion, Vascular Type of study: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Cardiovasc Radiat Med Journal subject: ANGIOLOGIA / CARDIOLOGIA Year: 2002 Type: Article Affiliation country: United States
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Collection: 01-internacional Database: MEDLINE Main subject: Strontium Radioisotopes / Beta Particles / Stents / Graft Occlusion, Vascular Type of study: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Cardiovasc Radiat Med Journal subject: ANGIOLOGIA / CARDIOLOGIA Year: 2002 Type: Article Affiliation country: United States