Determination of PNU-248686A, a novel matrix metalloproteinase inhibitor, in human plasma by liquid chromatography-tandem mass spectrometry, following protein precipitation in the 96-well plate format.

Frigerio, E; Cenacchi, V; James, C A

Frigerio, E; Cenacchi, V; James, C A.

Affiliation

Frigerio E; Global Drug Metabolism, Pharmacia, Viale Pasteur 10, 20014 Nerviano, Milan, Italy. enrico.frigerio@pharmacia.com

J Chromatogr A ; 987(1-2): 249-56, 2003 Feb 14.

Article in En | MEDLINE | ID: mdl-12613819

Subject(s)

Biphenyl Compounds/blood; Chromatography, Liquid/methods; Mass Spectrometry/methods; Matrix Metalloproteinase Inhibitors; Protease Inhibitors/blood; Sulfones/blood; Calibration; Humans; Reproducibility of Results; Sensitivity and Specificity

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Collection: 01-internacional Database: MEDLINE Main subject: Protease Inhibitors / Mass Spectrometry / Sulfones / Biphenyl Compounds / Chromatography, Liquid / Matrix Metalloproteinase Inhibitors Type of study: Diagnostic_studies Limits: Humans Language: En Journal: J Chromatogr A Year: 2003 Type: Article Affiliation country: Italy

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