Glucose-lowering effect of beta-phenylpyruvate in neonatal mice: a possible mechanism for phenylketonuria-related neurodegenerative changes.

Gazit, Vered; Ben-Abraham, Ron; Rudin, Michael; Katz, Yeshayahu

Gazit, Vered; Ben-Abraham, Ron; Rudin, Michael; Katz, Yeshayahu.

Affiliation

Gazit V; Laboratory for Anesthesia, Pain and Neural Research, The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

Brain Res Dev Brain Res ; 141(1-2): 137-40, 2003 Mar 14.

Article in En | MEDLINE | ID: mdl-12644257

Subject(s)

Blood Glucose/physiology; Brain/metabolism; Hypoglycemia/complications; Nerve Degeneration/metabolism; Neurons/metabolism; Phenylketonurias/metabolism; Phenylpyruvic Acids/metabolism; Animals; Animals, Newborn; Blood Glucose/drug effects; Brain/drug effects; Brain/growth & development; Disease Models, Animal; Dose-Response Relationship, Drug; Glucose/deficiency; Glucose/pharmacology; Hypoglycemia/metabolism; Hypoglycemia/physiopathology; Insulin/blood; Mice; Mice, Inbred ICR; Nerve Degeneration/chemically induced; Nerve Degeneration/physiopathology; Neurons/drug effects; Neurons/pathology; Phenylketonurias/pathology; Phenylketonurias/physiopathology; Phenylpyruvic Acids/pharmacology; Reaction Time/drug effects; Reaction Time/physiology; Survival Rate

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Collection: 01-internacional Database: MEDLINE Main subject: Phenylpyruvic Acids / Phenylketonurias / Blood Glucose / Brain / Hypoglycemia / Nerve Degeneration / Neurons Limits: Animals Language: En Journal: Brain Res Dev Brain Res Journal subject: CEREBRO / NEUROLOGIA Year: 2003 Type: Article Affiliation country: Israel

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