Effects of Crocus sativus petals' extract on rat blood pressure and on responses induced by electrical field stimulation in the rat isolated vas deferens and guinea-pig ileum.
J Ethnopharmacol
; 84(2-3): 199-203, 2003 Feb.
Article
in En
| MEDLINE
| ID: mdl-12648816
ABSTRACT
We have investigated the effects of Crocus sativus petals' extract on blood pressure in anaesthetised rats and also on responses of the isolated rat vas deferens and guinea-pig ileum induced by electrical field stimulation (EFS). Aqueous and ethanol extracts of C. sativus petals reduced the blood pressure in a dose-dependent manner. For example administration of 50 mg/100 g of aqueous extract changed the blood pressure from 133.5+/-3.9 to 117+/-2.1 (mmHg). EFS of the isolated rat vas deferens and guinea-pig ileum evoked contractions were decreased by aqueous and ethanol extracts of C. sativus petals. The aqueous extract (560 mg/ml) significantly reduced the contractile responses of vas deferens to epinephrine (1 microM) without any change in contraction induced by KCl (300 mM). The present results may suggest that the relaxatory action of C. sativus petals' extract on contraction induced by EFS in the rat isolated vas deferens is a postsynaptic effect.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Blood Pressure
/
Crocus
/
Muscle, Smooth
Limits:
Animals
Language:
En
Journal:
J Ethnopharmacol
Year:
2003
Type:
Article
Affiliation country:
Iran