Re-evaluating the role of heat-shock protein-peptide interactions in tumour immunity.
Nat Rev Immunol
; 3(5): 427-32, 2003 05.
Article
in En
| MEDLINE
| ID: mdl-12766764
ABSTRACT
Early investigations into the immune surveillance of chemically-induced sarcomas led to two important concepts in tumour immunobiology one, tumour rejection can be elicited by immune recognition of tumour antigens; and two, tumours express unique sets of antigens, which are known as tumour-specific antigens. The pioneering studies of Srivastava and colleagues led to the proposal that heat-shock proteins (HSPs) function as ubiquitous tumour-specific antigens, with the specificity residing in a population of bound peptides that identify the tissue of origin of the HSP. However, recent findings, including new data on the cell biology of peptide generation and trafficking, have called into question the specificity of tumour rejection that is induced by HSPs.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Heat-Shock Proteins
/
Neoplasms, Experimental
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Nat Rev Immunol
Journal subject:
ALERGIA E IMUNOLOGIA
Year:
2003
Type:
Article
Affiliation country:
United States