Effect of early graft function on patient survival in renal transplantation.
Transplant Proc
; 35(5): 1653-4, 2003 Aug.
Article
in En
| MEDLINE
| ID: mdl-12962744
ABSTRACT
The influence of early graft function on long-term graft survival has been widely reported but its association with patient survival has received less attention. We investigated the effect of early renal function on patient survival and on cardiovascular disease after renal transplantation among 532 transplant patients who had grafts functioning for >1 year. Patients were classified into two groups, depending on the early creatinine clearance (< or >60 mL/min). We analyzed graft and patient survival, posttransplant cardiovascular disease, and the principal causes of death. Five- and 10-year graft and patient survival were lower among the group with worse early renal function. The main cause of death was vascular disease. Poorer early renal function increased the risk (RR) of patient death by 2.2-fold, and also the presence of posttransplant cardiovascular disease. In conclusion, patients with poor levels of early graft function are at an increased risk of death. These high-risk groups should be targeted for interventional studies to improve patient survival.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Survival Rate
/
Kidney Transplantation
/
Graft Survival
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Male
Language:
En
Journal:
Transplant Proc
Year:
2003
Type:
Article
Affiliation country:
Spain