Induction of mucosal and systemic immunity to a recombinant simian immunodeficiency viral protein.
Science
; 258(5086): 1365-9, 1992 Nov 20.
Article
in En
| MEDLINE
| ID: mdl-1360702
ABSTRACT
Heterosexual transmission through the cervico-vaginal mucosa is the principal route of human immunodeficiency virus (HIV) infection in Africa and is increasing in the United States and Europe. Vaginal immunization with simian immunodeficiency virus (SIV) had not yet been studied in nonhuman primates. Immune responses in macaques were investigated by stimulation of the genital and gut-associated lymphoid tissue with a recombinant, particulate SIV antigen. Vaginal, followed by oral, administration of the vaccine elicited three types of immunity (i) gag protein p27-specific, secretory immunoglobulin A (IgA) and immunoglobulin G (IgG) in the vaginal fluid, (ii) specific CD4+ T cell proliferation and helper function in B cell p27-specific IgA synthesis in the genital lymph nodes, and (iii) specific serum IgA and IgG, with CD4+ T cell proliferative and helper functions in the circulating blood.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Vaccines, Synthetic
/
Gene Products, gag
/
Simian Acquired Immunodeficiency Syndrome
/
Simian Immunodeficiency Virus
Limits:
Animals
Language:
En
Journal:
Science
Year:
1992
Type:
Article
Affiliation country:
United kingdom