Four distinct antigenic regions are present in the primary structure of HIV-1 and HIV-2 proteinases.
AIDS
; 6(2): 157-63, 1992 Feb.
Article
in En
| MEDLINE
| ID: mdl-1373063
ABSTRACT
OBJECTIVE:
The purpose of this study was to assay reactivity of antibody-positive sera to different parts of the HIV-1 and HIV-2 proteinase (PR) proteins.DESIGN:
Since the majority of HIV-1-antibody-positive sera react to the proteinase, but the antigenic determinants on the protein have not been identified, we attempted to identify these determinants.INTERVENTIONS:
We synthesized 18 peptides representing the PR of HIV-1 and HIV-2 in order to map serum reactivity to the PR protein.RESULTS:
Both HIV-1- and HIV-2-antibody-positive sera recognized four distinct antigenic regions in the HIV-1 and HIV-2 PR.CONCLUSIONS:
Correlation between our results and the crystallographic structure of the protein revealed that the antigenic regions are positioned at the surface of the HIV-1 PR. Although the structure of HIV-2 PR has not yet been characterized, our results indicate that the folding of the HIV-1 and HIV-2 PR may be very similar.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
HIV Infections
/
HIV Protease
/
HIV-1
/
HIV-2
/
Epitopes
Limits:
Female
/
Humans
/
Male
Language:
En
Journal:
AIDS
Journal subject:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Year:
1992
Type:
Article
Affiliation country:
Sweden