Cytokines/physiology; Osteoclasts/physiology; Protein Kinases/physiology; Ribosomal Protein S6 Kinases, 70-kDa/metabolism; Acid Phosphatase/metabolism; Actins/metabolism; Adaptor Proteins, Signal Transducing; Alendronate/pharmacology; Alkyl and Aryl Transferases/antagonists & inhibitors; Animals; Apoptosis/drug effects; Blotting, Western; Bone Marrow Cells/cytology; Bone Marrow Cells/metabolism; Bone Resorption/metabolism; Bone Resorption/pathology; Carrier Proteins/metabolism; Carrier Proteins/pharmacology; Carrier Proteins/physiology; Caspase 3; Caspase 9; Caspases/metabolism; Cell Cycle Proteins; Cell Survival/drug effects; Collagen/metabolism; Collagen Type I; Cytokines/pharmacology; Diterpenes/pharmacology; Enzyme Inhibitors/pharmacology; Eukaryotic Initiation Factors; Immunohistochemistry; Interleukin-1/pharmacology; Isoenzymes/metabolism; Macrophage Colony-Stimulating Factor/pharmacology; Macrophage Colony-Stimulating Factor/physiology; Membrane Glycoproteins/pharmacology; Membrane Glycoproteins/physiology; Mice; Models, Biological; NF-kappa B/analysis; NF-kappa B/metabolism; Osteoclasts/cytology; Osteoclasts/drug effects; Peptides/metabolism; Phosphoproteins/metabolism; Protein Serine-Threonine Kinases/metabolism; Protein Synthesis Inhibitors/pharmacology; Proto-Oncogene Proteins/analysis; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins c-akt; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Ribosomal Protein S6/metabolism; Serine-Threonine Kinase 3