Induction of murine NAD(P)H:quinone oxidoreductase by 2,3,7,8-tetrachlorodibenzo-p-dioxin requires the CNC (cap 'n' collar) basic leucine zipper transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2): cross-interaction between AhR (aryl hydrocarbon receptor) and Nrf2 signal transduction.

Ma, Qiang; Kinneer, Krista; Bi, Yongyi; Chan, Jefferson Y; Kan, Yuet Wai

Ma, Qiang; Kinneer, Krista; Bi, Yongyi; Chan, Jefferson Y; Kan, Yuet Wai.

Affiliation

Ma Q; Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA. qam1@cdc.gov

Biochem J ; 377(Pt 1): 205-13, 2004 Jan 01.

Article in En | MEDLINE | ID: mdl-14510636

Subject(s)

DNA-Binding Proteins/physiology; NAD(P)H Dehydrogenase (Quinone)/biosynthesis; Polychlorinated Dibenzodioxins/pharmacology; Receptors, Aryl Hydrocarbon/metabolism; Trans-Activators/physiology; Animals; Antioxidants/pharmacology; Cell Line, Tumor; Cells, Cultured; Cycloheximide/pharmacology; Cysteine Endopeptidases/metabolism; DNA-Binding Proteins/chemistry; DNA-Binding Proteins/metabolism; Enzyme Induction; Hydroquinones/pharmacology; Leucine Zippers; Ligands; Mice; Multienzyme Complexes/metabolism; NAD(P)H Dehydrogenase (Quinone)/genetics; NAD(P)H Dehydrogenase (Quinone)/metabolism; NF-E2-Related Factor 2; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors/pharmacology; Signal Transduction; Trans-Activators/chemistry; Trans-Activators/metabolism; Transcription, Genetic; Ubiquitins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Trans-Activators / NAD(P)H Dehydrogenase (Quinone) / Receptors, Aryl Hydrocarbon / DNA-Binding Proteins / Polychlorinated Dibenzodioxins Limits: Animals Language: En Journal: Biochem J Year: 2004 Type: Article Affiliation country: United States

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