Peptide-treated stent graft for the treatment of saphenous vein graft lesions: first clinical results.
J Invasive Cardiol
; 15(10): 557-60, 2003 Oct.
Article
in En
| MEDLINE
| ID: mdl-14519886
ABSTRACT
UNLABELLED Percutaneous interventions of degenerated saphenous vein grafts (SVG) are associated with high rates of distal embolic events and in-stent restenosis. A novel ePTFE-covered stent graft has been developed to improve outcomes for these difficult lesions. The stent graft has been treated with a 15-amino acid, cell adhesion peptide (P-15) to promote endothelialization on the inner surface post-implantation. Patients with de novo lesions in SVGs were treated with a peptide-coated ePTFE stent graft. Follow-up data was collected at 30 days, 3 and 6 months. An angiographic core lab analyzed an angiographic follow-up at 6 months. RESULTS:
Procedural success was achieved in all cases. No device-related major adverse cardiac events occurred in-hospital, at 30 days, or at 3 months, despite the lack of distal protection. Six-month restenosis rates were 21%, and were comparable to similar devices.CONCLUSIONS:
The peptide-treated stent graft appears to be a safe and effective treatment for SVG lesions, and has the potential to reduce complications without the use of adjunct distal protection in this patient population.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peptide Fragments
/
Polytetrafluoroethylene
/
Saphenous Vein
/
Vascular Surgical Procedures
/
Coronary Artery Bypass
/
Collagen
/
Coated Materials, Biocompatible
/
Graft Occlusion, Vascular
Type of study:
Clinical_trials
/
Observational_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Invasive Cardiol
Journal subject:
CARDIOLOGIA
Year:
2003
Type:
Article
Affiliation country:
Germany