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Synthesis of halogenated 9-(dihydroxycyclopent-4'-enyl) adenines and their inhibitory activities against S-adenosylhomocysteine hydrolase.
Jeong, Lak Shin; Park, Jae Gyu; Choi, Won Jun; Moon, Hyung Ryong; Lee, Kang Man; Kim, Hea Ok; Kim, Hee-Doo; Chun, Moon Woo; Park, Hea-Young; Kim, Kilhyoun; Sheen, Yhun Y.
Affiliation
  • Jeong LS; College of Pharmacy, Ewha Womans University, Seoul, South Korea. lakjeong@ewha.ac.kr
Nucleosides Nucleotides Nucleic Acids ; 22(5-8): 919-21, 2003.
Article in En | MEDLINE | ID: mdl-14565311
ABSTRACT
Novel halovinyl analogues of neplanocin A without 4'-hydroxymethyl group were easily synthesized starting from D-ribose via cyclopentenone 5 as a key intermediate and their inhibitory activity against SAH hydrolase was assayed.
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Collection: 01-internacional Database: MEDLINE Main subject: Adenine / Adenosylhomocysteinase / Enzyme Inhibitors Language: En Journal: Nucleosides Nucleotides Nucleic Acids Journal subject: BIOQUIMICA Year: 2003 Type: Article Affiliation country: South Korea
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Collection: 01-internacional Database: MEDLINE Main subject: Adenine / Adenosylhomocysteinase / Enzyme Inhibitors Language: En Journal: Nucleosides Nucleotides Nucleic Acids Journal subject: BIOQUIMICA Year: 2003 Type: Article Affiliation country: South Korea