Alpha4beta1 integrin mediates selective endothelial cell responses to thrombospondins 1 and 2 in vitro and modulates angiogenesis in vivo.

Calzada, Maria J; Zhou, Longen; Sipes, John M; Zhang, Jane; Krutzsch, Henry C; Iruela-Arispe, M Luisa; Annis, Douglas S; Mosher, Deane F; Roberts, David D

Calzada, Maria J; Zhou, Longen; Sipes, John M; Zhang, Jane; Krutzsch, Henry C; Iruela-Arispe, M Luisa; Annis, Douglas S; Mosher, Deane F; Roberts, David D.

Affiliation

Calzada MJ; Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Md 20892-1500, USA.

Circ Res ; 94(4): 462-70, 2004 Mar 05.

Article in En | MEDLINE | ID: mdl-14699013

Subject(s)

Endothelium, Vascular/drug effects; Integrin alpha4beta1/physiology; Neovascularization, Physiologic/drug effects; Thrombospondin 1/pharmacology; Thrombospondins/pharmacology; Animals; Capillaries/cytology; Cell Adhesion/drug effects; Cell Division/drug effects; Chemotaxis/drug effects; Fibroblast Growth Factor 2/antagonists & inhibitors; Humans; Iliac Vein; Lung; Mice; Mice, Knockout; Organ Specificity; Peptide Fragments/pharmacology; Protein Structure, Tertiary; RNA Interference; RNA, Messenger/biosynthesis; Skin; Thrombospondin 1/chemistry; Thrombospondin 1/deficiency; Thrombospondins/biosynthesis; Thrombospondins/chemistry; Thrombospondins/genetics; Umbilical Veins/cytology; Vascular Cell Adhesion Molecule-1/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Endothelium, Vascular / Neovascularization, Physiologic / Thrombospondins / Thrombospondin 1 / Integrin alpha4beta1 Limits: Animals / Humans Language: En Journal: Circ Res Year: 2004 Type: Article Affiliation country: United States

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